GS3 · 10 marks · 150 words

Discuss the potential of RNA editing in treating genetic disorders. What are its advantages over DNA editing?

Answered by 4 toppers · CSE 2023–2025

BiotechnologyEmerging Technologies

Syllabus: Science and Technology- developments and their applications and effects in everyday life.

How toppers approached it

From all 4 answers · about 170 words · 25% drew a diagram.

Opening

  • A definition2 of 4
  • No separate opening2 of 4

Body

  • Points3 of 4
  • Points and prose1 of 4

Close

  • No separate close2 of 4
  • A way forward2 of 4

The toppers’ answers

Pakshal SecretryAIR 8 · CSE 2025 · 158 wordsTheir whole copy

Opening

RNA editing is a system of treating disorders by two process

gene silencing

gene attenuation

Body · points

Potential →

  1. Solving monogenetic disorder (eg - sickle cell anemia)
  2. use in oncology (eg cancer treatment)
  3. solution to unresolved disease (eg HIV, AIDS)
  4. silencing of gene expression → only desirable traits

Advantages

  1. Does not alter or cause damage to human DNA (DNA Editing might cause)

(2) Limited/No side effect → precise editing by CRISPR

(3) High Efficiency

  • RNA: 99% due to CRISPR Cas 9
  • DNA: 80-90% due to CRISPR-Cas 13

(4) Simple process → only translation in RNA editing → no transcription (DNA Editing)

(5) Easier delivery of genetic material → Cas 9 smaller in size

(6) No changes in germ line (any miseffect does not get transmitted)

Limitation → low shelf life of RNA → Frequent Re-treatment Needs → Doesnt solve Root cause

Close

Recent Nobel 2024 for RNA Editing is testimony to its future potential

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