GS3 · 10 marks · 150 words

Global health experts widely believe that the development of CAR-T cell therapy can be a game changer in the treatment of cancer. How can CAR-T cell therapy overcome the limitations of CRISPR-Cas9 technology?

Answered by 4 toppers · CSE 2023–2025

BiotechnologyEmerging Technologies

Syllabus: Science and Technology- developments and their applications and effects in everyday life.

How toppers approached it

From all 4 answers · about 140 words · 50% drew a diagram.

Opening

  • A definition3 of 4
  • No separate opening1 of 4

Body

  • Points3 of 4
  • Points and prose1 of 4

Close

  • A way forward2 of 4
  • No separate close1 of 4
  • A summary1 of 4

The toppers’ answers

Animesh PradhanAIR 2 · CSE 2023 · 106 wordsTheir whole copy

Opening

With high incidence of cancer fuelled by modern lifestyle and enormous expenditure on its treatment (Jairam Ramesh committee - PSC), technological interventions like CAR-T can be a major breakthrough.

Body · points and prose

→ (CAR-T) Chimeric Antigen Receptor-T cell uses genetic engineering to alter the immunity delivering T-cell that could encode targeted protein to kill the cancerous cells.

→ This is an advancement to CRISPR-Cas9 technology where Cas9 protein was used with genetic scissor technology to encode targeted genes to tackle cancerous cells.

Diagram
- Central Node: CAR-T can overcome limitations of CRISPR-9 - Arrow 1: Requires minimal infusion in body and reduces frequencies of hospital visits - Arrow 2: Reduces the risk of body's repulsiveness → more effectiveness - Arrow 3: Low cost and more scalable than CRISPR-9 - Arrow 4: less side effects as compared to CRISPR-9 - Arrow 5: Targetted approach of CAR-T has better prognosis & survival rate as compared to CRISPR-9 - Arrow 6: CRISPR-9 requires stringent laboratory condition for Cas9 protein to be activated - difficult to achieve.

Close

So, cancer survivors are not warriors, but the ones who is going through the treatment itself is one, CAR-T therapy becomes the largest weapon in this fight.

More on Biotechnology

Genetic modification, gene editing, vaccines and biopharma, biosafety regulation, agricultural biotech.

All GS3 questions on Biotechnology